- Comfort Inn Guelph
- Delta Hotels by Marriott Guelph Conference Centre
- Fairfield Inn & Suites by Marriott Guelph
- Hampton Inn & Suites by Hilton Guelph
- Holiday Inn Express & Suites Guelph
- Norfolk Guest House
- Royal Inn and Suites
- Staybridge Suites Guelph
- Super 8 by Wyndham Guelph
- Western Hotel & Executive Suites